Nexus of Coagulation and Inflammation

A major evolutionary advantage that protects us from invading pathogens uses two major host defense systems: innate immune or inflammation, and coagulation.  These systems are linked throughout evolution and one of the best examples of this is found in the ancient horseshoe crab (Limulus polyphemus) that is so abundant on the mid-Atlantic to New England shorelines, with its linked immune and semi-closed circulatory system. In the 1950’s and 60’s horseshoe crab became the basis for the Limulus lysate test that is used worldwide to detect elevated levels of endotoxin (lipopolysaccharide or LPS) in the bloodstream.

At pHLOGISTIX we are researching critical pathways involving coagulation and inflammation in the brain to develop innovative new drugs to help athletes, soldiers, veterans and anyone with various brain injuries live longer, healthier lives.